Welcome to the Arnold Lab
In the Arnold Lab we explore the role of myeloid innate cells, particularly eosinophils, in maintaining mucosal homeostasis, driving inflammation, and contributing to cancer development.
The research
We are using several models of colitis, bacterial infections, asthma and colorectal cancer, together with new tools specifically targeting the eosinophil lineage, to investigate the pathways used by eosinophils to sense activating cytokine and bacterial signals, and the mechanisms through which these activating signals translate into a functional response.
Cancer
Using cutting-edge technologies such as single-cell RNA sequencing, single-cell scale spatial transcriptomics and spectral flow cytometry, we aim to uncover the intricacies of the tumor microenvironment by studying eosinophil dynamics in both mouse models and patients.
Asthma
Eosinophils are important drivers of airway inflammation, and identifying the mechanisms that underlie their activities may contribute to finding new therapeutic targets.
Homeostatis
Gut health is maintained by a complex interplay between the tissue-resident immune cells and the microbiota. Disturbances in this balance may cause an inflammatory reaction, where distinct eosinophil subsets have been shown to impact disease outcomes.
open positions
We are always looking for motivated students/postdocs that are interested in our research. Applications should be directly sent to Prof. Dr. Isabelle Arnold, including your CV and a short paragraph of your scientific interest.
Additionally, PhD students can apply through the Life Science Zürich Graduate school, which holds selections twice a year.